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Drug ReportsFosfomycin tromethamine
Fosfomycin tromethamine
Fosfomycin Tromethamine, Monurol (fosfomycin tromethamine) is a small molecule pharmaceutical. Fosfomycin tromethamine was first approved as Monurol on 1996-12-19. It is used to treat escherichia coli infections, gram-positive bacterial infections, klebsiella infections, proteus infections, and serratia infections amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
urogenital diseasesD000091642
Trade Name
FDA
EMA
Fosfomycin tromethamine (discontinued: Monurol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fosfomycin tromethamine
Tradename
Company
Number
Date
Products
MONUROLZambonN-050717 DISCN1996-12-19
1 products, RLD
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FDA
EMA
Brand Name
Status
Last Update
fosfomycin tromethamineANDA2024-10-22
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
urinary tract infectionsEFO_0003103D014552N39.0
escherichia coli infectionsEFO_1001318D004927B96.20
proteus infectionsEFO_1001130D011512—
gram-positive bacterial infections—D016908—
klebsiella infectionsEFO_1001353D007710—
serratia infectionsEFO_1001421D016868—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01X: Other antibacterials in atc
— J01XX: Other antibacterials in atc
— J01XX01: Fosfomycin
HCPCS
No data
Clinical
Clinical Trials
75 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_0000544—————11
Communicable diseasesD003141——————11
Bacterial infectionsD001424—A49————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFosfomycin tromethamine
INN—
Description
Fosfomycin is a phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus. It has a role as an antimicrobial agent and an EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor. It is an epoxide and a member of phosphonic acids. It is functionally related to a phosphonic acid. It is a conjugate acid of a (1R,2S)-epoxypropylphosphonate(1-).
Classification
Small molecule
Drug classphosphoro-derivatives; antibiotics (Streptomyces strain)
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Structure (InChI/SMILES or Protein Sequence)
C[C@@H]1O[C@@H]1P(=O)(O)O.NC(CO)(CO)CO
Identifiers
PDB—
CAS-ID23155-02-4
RxCUI4550
ChEMBL IDCHEMBL1200331
ChEBI ID—
PubChem CID446987
DrugBankDB00828
UNII ID—
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 13,774 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,866 adverse events reported
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